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中英“医”译
  • 作者:彭雪梅 张武宁摘译 房晓旭校对 2013-8-29
  •     Association between glycated haemoglobin and the risk of congestive heart failure in diabetes mellitus
        Clinical trials to date have not provided definitive evidence regarding the effects of glucose lowering on the incidence of congestive heart failure (CHF). We synthesized available prospective epidemiological data on the association between glycaemia measured by haemoglobin A(1c) (HbA(1c)) and incident CHF in individuals with diabetes. We searched electronic databases and reference lists of selected articles for relevant prospective epidemiological studies. We abstracted data from relevant studies using standardized forms and obtained additional data from investigators when required. We pooled study-specific relative risk estimates using random-effects model meta-analysis. Of the 1044 citations identified, we included 10 studies comprising 178 929 participants with diabetes and 14 176 incident CHF cases. Five studies included only patients with type 2 diabetes, four studies had predominantly patients with type 2 diabetes, and one study included only patients with type 1 diabetes. All studies except one showed an increased risk of CHF with higher HbA(1c). In observational studies of individuals with diabetes, a higher HbA1c level was associated with a significantly increased incidence of CHF.

        译文:糖尿病中糖化血红蛋白水平与充血性心力衰竭的风险关联分析
        美国匹兹堡大学Sebhat Erqou和加拿大多伦多大学Chee-Tin Christine Lee等研究学者通过电子数据库检索相关的前瞻性流行病学资料和参考文献从10项研究中入选178929例糖尿病(I型或II型糖尿病)患者,其中有14176 例发生心力衰竭。通过建立回归模型探讨糖化血红蛋白(HbA(1c))水平与心衰风险的关系。研究发现:有较高HbA(1c)水平的糖尿病患者其心衰风险明显增加:HbA(1c)每增加1%心衰的风险即增加15%。其潜在因果关系已经被一些生物学机制解释:HbA(1c)升高会增加患者冠心病的患病率,其次还会通过糖化终末产物和氧化应激反应引起高血糖和高胰岛素血症最终可能导致收缩压和舒张压增高。